EmbryoGlue© is an implantation promoting transfer medium with a unique combination of hyaluronic acid and recombinant albumin.
The addition of a high concentration of hyaluronic acid (HA) in a transfer medium, such as EmbryoGlue, increases live births after IVF according to a published meta-analysis from the independent research network Cochrane Collaboration. When using EmbryoGlue for transfer, there was an overall increase of 8% in the live birth rate, compared to a medium with low or no HA. The positive effect was seen regardless of embryo transfer day.
How does it work?
EmbryoGlue© contains all nutrients and energy sources needed for an optimal embryo development. It contains a high concentration of implantation promoting hyaluronan, which is the major glycosaminoglycan present in the follicular, oviductal and uterine fluids. The physiological concentrations in these fluids provide high viscosity environments in the oviduct and uterus.
The synthesis of hyaluronan increases dramatically on the day of implantation and decreases to near basal levels by the next day, indicating that it is important for implantation.
EmbryoGlue has the basic composition of a rich blastocyst culture medium and contains a high concentration of hyaluronan and recombinant human albumin. It can be used for transfer of all embryo developmental stages, including embryos after assisted hatching, biopsy and cryopreservation.
EmbryoGlue is routinely used in assisted conception cycles performed by Cheshire Fertility and Gynaecology.